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1

High-Permeability Criterion for BCS Classification: Segmental/pH Dependent Permeability Considerations

Dahan, Arik, Miller, Jonathan M., Hilfinger, John M., Yamashita, Shinji, Yu, Lawrence X., Lennernäs, Hans, Amidon, Gordon L.

Journal:

Molecular Pharmaceutics

Year:

2010

Language:

english

File:

PDF, 552 KB

english, 2010

2

Increasing Oral Absorption of Polar Neuraminidase Inhibitors: A Prodrug Transporter Approach Applied to Oseltamivir Analogue

Gupta, Deepak, Varghese Gupta, Sheeba, Dahan, Arik, Tsume, Yasuhiro, Hilfinger, John, Lee, Kyung-Dall, Amidon, Gordon L.

Journal:

Molecular Pharmaceutics

Year:

2013

Language:

english

File:

PDF, 1.03 MB

english, 2013

3

Synthesis and biological activation of an ethylene glycol-linked amino acid conjugate of cyclic cidofovir

Ulrika Eriksson, John M. Hilfinger, Jae-Seung Kim, Stefanie Mitchell, Paul Kijek, Katherine Z. Borysko, Julie M. Breitenbach, John C. Drach, Boris A. Kashemirov, Charles E. McKenna

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 148 KB

english, 2007

4

Design and synthesis of vidarabine prodrugs as antiviral agents

Wei Shen, Jae-Seung Kim, Phillip E. Kish, Jie Zhang, Stefanie Mitchell, Brian G. Gentry, Julie M. Breitenbach, John C. Drach, John Hilfinger

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 187 KB

english, 2009

5

Synthesis, transport and antiviral activity of Ala–Ser and Val–Ser prodrugs of cidofovir

Larryn W. Peterson, Jae-Seung Kim, Paul Kijek, Stefanie Mitchell, John Hilfinger, Julie Breitenbach, Kathy Borysko, John C. Drach, Boris A. Kashemirov, Charles E. McKenna

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 547 KB

english, 2011

6

Floxuridine Amino Acid Ester Prodrugs: Enhancing Caco-2 Permeability and Resistance to Glycosidic Bond Metabolism

Christopher P. Landowski, Xueqin Song, Philip L. Lorenzi, John M. Hilfinger, Gordon L. Amidon

Journal:

Pharmaceutical Research

Year:

2005

Language:

english

File:

PDF, 444 KB

english, 2005

7

Pharmacokinetics of the CYP 3A Substrate Simvastatin following Administration of DelayedVersusImmediate Release Oral Dosage Forms

Marija Tubic-Grozdanis, John M. Hilfinger, Gordon L. Amidon, Jae Seung Kim, Paul Kijek, Petra Staubach, Peter Langguth

Journal:

Pharmaceutical Research

Year:

2008

Language:

english

File:

PDF, 212 KB

english, 2008

8

Potential of Amino Acid/Dipeptide Monoester Prodrugs of Floxuridine in Facilitating Enhanced Delivery of Active Drug to Interior Sites of Tumors: A Two-Tier MonolayerIn VitroStudy

Yasuhiro Tsume, John M. Hilfinger, Gordon L. Amidon

Journal:

Pharmaceutical Research

Year:

2011

Language:

english

File:

PDF, 814 KB

english, 2011

9

Oral absorption of phytosterols and emulsified phytosterols by Sprague-Dawley rats

Bryan Delaney, Luke A Stevens, Wade Schmelzer, James Haworth, Steve McCurry, John M Hilfinger, Jae Seung Kim, Yasuhiro Tsume, Gordon L Amidon, David Kritchevsky

Journal:

The Journal of Nutritional Biochemistry

Year:

2004

Language:

english

File:

PDF, 94 KB

english, 2004

10

Cidofovir peptide conjugates as prodrugs

Charles E. McKenna, Boris A. Kashemirov, Ulrika Eriksson, Gordon L. Amidon, Phillip E. Kish, Stefanie Mitchell, Jae-Seung Kim, John M. Hilfinger

Journal:

Journal of Organometallic Chemistry

Year:

2005

Language:

english

File:

PDF, 151 KB

english, 2005

11

HT29-MTX/Caco-2 cocultures as an in vitro model for the intestinal epithelium: In vitro–in vivo correlation with permeability data from rats and humans

Elke Walter, Sonia Janich, Blake J. Roessler, John M. Hilfinger, Gordon L. Amidon

Journal:

Journal of Pharmaceutical Sciences

Year:

1996

Language:

english

File:

PDF, 609 KB

english, 1996

12

Overexpression of Human Intestinal Oligopeptide Transporter in Mammalian Cells via Adenoviral Transduction

Cheng-Pang Hsu, John M. Hilfinger, Elke Walter, Hans P. Merkle, Blake J. Roessler, Gordon L. Amidon

Journal:

Pharmaceutical Research

Year:

1998

File:

PDF, 569 KB

1998

13

Bile Acid−Oligopeptide Conjugates Interact with DNA and Facilitate Transfection

Kish, Phillip E., Tsume, Yasuhiro, Kijek, Paul, Lanigan, Thomas M., Hilfinger, John M., Roessler, Blake J.

Journal:

Molecular Pharmaceutics

Year:

2007

Language:

english

File:

PDF, 221 KB

english, 2007

14

ChemInform Abstract: Expedient Total Synthesis of Triciribine and Its Prodrugs.

Wei Shen, Jae-Seung Kim, John Hilfinger

Journal:

Year:

2012

File:

PDF, 33 KB

2012

15

Synthesis and Structure–Activity Aspects of Some Cyclic Cidofovir Peptidomimetic Prodrugs

Larryn W. Peterson, Boris A. Kashemirov, Katarzyna M. Blazewska, Julie Breitenback, Kathy Borysko, John C. Drach, Jae Seung Kim, Paul Kijek, John M. Hilfinger, Charles E. McKenna

Journal:

Antiviral Research

Year:

2007

Language:

english

File:

PDF, 74 KB

english, 2007

16

Bile Acid Conjugates Improve the Oral Bioavailability of the Neurominidase Inhibitor Zanamivir

Phillip Kish, Jae Seung Kim, Blake Roessler, Shelby Campbell, John Hilfinger

Journal:

Antiviral Research

Year:

2007

Language:

english

File:

PDF, 68 KB

english, 2007

17

Novel Synthetic Approaches to Cidofovir and Foscarnet Prodrugs

Larryn W. Peterson, Boris A. Kashemirov, Kanokkarn Saejueng, Julie Breitenbach, Kathy Borysko, John C. Drach, Jae Seung Kim, Paul Kijek, Stefanie Mitchell, John M. Hilfinger, Charles E. McKenna

Journal:

Antiviral Research

Year:

2007

Language:

english

File:

PDF, 60 KB

english, 2007

18

Vidarabine Prodrugs as Potential Inhibitors of Adenosine Deaminase

Brian G. Gentry, Wei Shen, Julie M. Breitenbach, John Hilfinger, John C. Drach

Journal:

Antiviral Research

Year:

2008

Language:

english

File:

PDF, 111 KB

english, 2008

19

Serine Side-Chain-linked Peptidomimetic Prodrugs of Cidofovir and Cyclic Cidofovir: C-Ester Effects on Transport and Activation

Larryn W. Peterson, Boris A. Kashemirov, Ulrika Eriksson, Jae-Seung Kim, Stefanie Mitchell, Paul Kijek, Kyung-Dall Lee, John M. Hilfinger, Charles E. McKenna

Journal:

Antiviral Research

Year:

2008

Language:

english

File:

PDF, 70 KB

english, 2008

20

Synthesis and Activity of Vidarabine d-Amino Acid Prodrugs as Potential Pox Virus Agents

Julie M. Breitenbach, Wei Shen, John Hilfinger, John C. Drach

Journal:

Antiviral Research

Year:

2008

Language:

english

File:

PDF, 85 KB

english, 2008

21

Synthesis of P–O–C-linked Foscarnet–Peptide Conjugates and Sensitive Methods to Detect the Released Drug in Biological Samples

Chi V. Pham, Boris A. Kashemirov, Jorge Osuna, Kanokkarn Saejueng, John M. Hilfinger, Charles E. McKenna

Journal:

Antiviral Research

Year:

2008

Language:

english

File:

PDF, 72 KB

english, 2008

22

Interactions Between the Human Oligopeptide Transporter, hPepT1 and Serine Side-chain-linked Cidofovir Prodrugs

Monica Sala-Rabanal, Larryn W. Peterson, Michaela Serpi, Ivan S. Krylov, Boris A. Kashemirov, Jae Seung Kim, Stefanie Mitchell, John M. Hilfinger, Charles E. McKenna

Journal:

Antiviral Research

Year:

2009

Language:

english

File:

PDF, 93 KB

english, 2009

23

New peptidomimetic prodrugs of acyclic and cyclic cidofovir: sar studies of chemical and enzymatic activation mechanisms

Charles E. McKenna, Larryn W. Peterson, Boris A. Kashemirov, Michaela Serpi, Stefanie Mitchell, Jae Seung Kim, John M. Hilfinger, John C. Drach

Journal:

Antiviral Research

Year:

2009

Language:

english

File:

PDF, 72 KB

english, 2009

24

In vitro transport, activation and antiviral evaluation of new HPMPA prodrugs synthesized on a solid support

Ivan S. Krylov, Larryn W. Peterson, Boris A. Kashemirov, Julie Breitenbach, Kathy Borysco, John C. Drach, Jae Seung Kim, John M. Hilfinger, Charles E. McKenna

Journal:

Antiviral Research

Year:

2009

Language:

english

File:

PDF, 72 KB

english, 2009

25

Puromycin-sensitive aminopeptidase: An antiviral prodrug activating enzyme

Ulrika Tehler, Cara H. Nelson, Larryn W. Peterson, Chester J. Provoda, John M. Hilfinger, Kyung-Dall Lee, Charles E. McKenna, Gordon L. Amidon

Journal:

Antiviral Research

Year:

2010

Language:

english

File:

PDF, 449 KB

english, 2010

26

Amido tyrosine esters: a promising new approach to antiviral nucleoside phosphonate prodrugs

Charles E. McKenna, Boris A. Kashemirov, Valeria M. Zakharova, Ivan S. Krylov, Melissa Williams, Marcela Krečmerová, John C. Drach, John M. Hilfinger

Journal:

Antiviral Research

Year:

2011

Language:

english

File:

PDF, 87 KB

english, 2011

27

Adenovirus mediated gene transfer to intestinal epithelial cells as a potential approach for oral delivery of peptides and proteins

Elke Walter, Maria A Croyle, Beverly L Davidson, Blake J Roessler, John M Hilfinger, Gordon L Amidon

Journal:

Journal of Controlled Release

Year:

1997

Language:

english

File:

PDF, 2.35 MB

english, 1997

28

Extended release of adenovirus from polymer microspheres: potential use in gene therapy for brain tumors

Steven J Beer, John M Hilfinger, Beverly L Davidson

Journal:

Advanced Drug Delivery Reviews

Year:

1997

Language:

english

File:

PDF, 687 KB

english, 1997

29

Proline prodrug of melphalan, prophalan-l, demonstrates high therapeutic index in a murine melanoma model

Sachin Mittal, Yasuhiro Tsume, Christopher P. Landowski, Kyung-Dall Lee, John M. Hilfinger, Gordon L. Amidon

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Year:

2007

Language:

english

File:

PDF, 159 KB

english, 2007

30

Function and immunolocalization of overexpressed human intestinal H+/peptide cotransporter in adenovirus-transduced Caco-2 cells

Cheng-Pang Hsu, Elke Walter, Hans P. Merkle, Barbara Rothen-Rutishauser, Heidi Wunderli-Allenspach, John M. Hilfinger, Gordon L. Amidon

Journal:

The AAPS Journal

Year:

1999

Language:

english

File:

PDF, 819 KB

english, 1999

31

Factors that Influence Stability of Recombinant Adenoviral Preparations for Human Gene Therapy

Croyle, Maria A., Roessler, Blake J., Davidson, Beverly L., Hilfinger, John M., Amidon, Gordon L.

Journal:

Pharmaceutical Development and Technology

Year:

1998

Language:

english

File:

PDF, 934 KB

english, 1998

32

Recombinant adenovirus serotype switching for analysis of efficiency and route of intestinalcell entry

Joel R. Chamberlain, Micheal H. Shaw, John M. Hilfinger, Ellen M. Zimmerman, Blake J. Roessler

Journal:

Gastroenterology

Year:

2000

Language:

english

File:

PDF, 180 KB

english, 2000

33

Blockade of the Renin-Angiotensin System (RAS) Prevents Acute and Immunologically-Relevant Colitis Murine Models

Manabu Okawada, Hiroyuki Koga, Scott D. Larsen, Michael W. Wilson, Elke Lipka, John Hilfinger, Daniel H. Teitelbaum

Journal:

Gastroenterology

Year:

2011

Language:

english

File:

PDF, 156 KB

english, 2011

34

Amino Acid Ester Prodrugs of the Anticancer Agent Gemcitabine: Synthesis, Bioconversion, Metabolic Bioevasion, and hPEPT1-Mediated Transport

Song, Xueqin, Lorenzi, Philip L., Landowski, Christopher P., Vig, Balvinder S., Hilfinger, John M., Amidon, Gordon L.

Journal:

Molecular Pharmaceutics

Year:

2005

Language:

english

File:

PDF, 110 KB

english, 2005

35

Evolution of an Amino Acid Based Prodrug Approach: Stay Tuned

Krylov, Ivan S., Kashemirov, Boris A., Hilfinger, John M., McKenna, Charles E.

Journal:

Molecular Pharmaceutics

Year:

2013

Language:

english

File:

PDF, 2.23 MB

english, 2013

36

The Suitability of an in Situ Perfusion Model for Permeability Determinations: Utility for BCS Class I Biowaiver Requests

Kim, Jae-Seung, Mitchell, Stefanie, Kijek, Paul, Tsume, Yasuhiro, Hilfinger, John, Amidon, Gordon L.

Journal:

Molecular Pharmaceutics

Year:

2006

Language:

english

File:

PDF, 219 KB

english, 2006

37

Enhancing the Intestinal Membrane Permeability of Zanamivir: A Carrier Mediated Prodrug Approach

Varghese Gupta, Sheeba, Gupta, Deepak, Sun, Jing, Dahan, Arik, Tsume, Yasuhiro, Hilfinger, John, Lee, Kyung-Dall, Amidon, Gordon L.

Journal:

Molecular Pharmaceutics

Year:

2011

Language:

english

File:

PDF, 1.23 MB

english, 2011

38

Serine Peptide Phosphoester Prodrugs of Cyclic Cidofovir: Synthesis, Transport, and Antiviral Activity

Eriksson, Ulrika, Peterson, Larryn W., Kashemirov, Boris A., Hilfinger, John M., Drach, John C., Borysko, Katherine Z., Breitenbach, Julie M., Kim, Jae Seung, Mitchell, Stefanie, Kijek, Paul, McKenna,

Journal:

Molecular Pharmaceutics

Year:

2008

Language:

english

File:

PDF, 617 KB

english, 2008

39

The development of orally administrable gemcitabine prodrugs with d-enantiomer amino acids: Enhanced membrane permeability and enzymatic stability

Tsume, Yasuhiro, Incecayir, Tuba, Song, Xueqin, Hilfinger, John M., Amidon, Gordon L.

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Year:

2014

Language:

english

File:

PDF, 638 KB

english, 2014

40

Cytokine gene transfer via oral composite nanoparticles to intestinal tissue of IL-10 deficient mice

Parks, Elizabeth, Hilfinger, John M., Zimmermann, Ellen M., Roessler, Blake J.

Journal:

Gastroenterology

Year:

2000

Language:

english

File:

PDF, 178 KB

english, 2000

41

Bacteriophage T4 ribonucleoside diphosphate reductase: on the defect causing decreased formation of the β293 subunit encoded by the nrdB93 mutant gene

Hilfinger, John M., He, Ping

Journal:

Year:

1994

Language:

english

File:

PDF, 1.02 MB

english, 1994

42

Tyrosine-Based 1-( S )-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine and -adenine (( S )-HPMPC and ( S )-HPMPA) Prodrugs: Synthesis, Stability, Antiviral Activity, and in Vivo Transport Studies

Zakharova, Valeria M., Serpi, Michaela, Krylov, Ivan S., Peterson, Larryn W., Breitenbach, Julie M., Borysko, Katherine Z., Drach, John C., Collins, Mindy, Hilfinger, John M., Kashemirov, Boris A., Mc

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.36 MB

english, 2011

43

Solving the Prodrug Design and Activation Puzzle

Hilfinger, John

Journal:

Molecular Pharmaceutics

Year:

2013

Language:

english

File:

PDF, 118 KB

english, 2013

44

BCS in Drug Discovery, Development, and Regulation

Hilfinger, John M.

Journal:

Molecular Pharmaceutics

Year:

2009

Language:

english

File:

PDF, 36 KB

english, 2009

45

Expedient Total Synthesis of Triciribine and Its Prodrugs

Shen, Wei, Kim, Jae-Seung, Hilfinger, John

Journal:

Synthetic Communications

Year:

2012

Language:

english

File:

PDF, 555 KB

english, 2012

46

Enhanced Cancer Cell Growth Inhibition by Dipeptide Prodrugs of Floxuridine: Increased Transporter Affinity and Metabolic Stability

Tsume, Yasuhiro, Hilfinger, John M., Amidon, Gordon L.

Journal:

Molecular Pharmaceutics

Year:

2008

Language:

english

File:

PDF, 425 KB

english, 2008

47

Cytomegalovirus Protease Targeted Prodrug Development

Sabit, Hairat, Dahan, Arik, Sun, Jing, Provoda, Chester J., Lee, Kyung-Dall, Hilfinger, John H., Amidon, Gordon L.

Journal:

Molecular Pharmaceutics

Year:

2013

Language:

english

File:

PDF, 1.06 MB

english, 2013

48

Prolidase, a Potential Enzyme Target for Melanoma: Design of Proline-Containing Dipeptide-like Prodrugs

Mittal, Sachin, Song, Xueqin, Vig, Balvinder S., Landowski, Christopher P., Kim, Insook, Hilfinger, John M., Amidon, Gordon L.

Journal:

Molecular Pharmaceutics

Year:

2005

Language:

english

File:

PDF, 261 KB

english, 2005

49

5′-O-D-Valyl ara A, A Potential Prodrug for Improving Oral Bioavailability of the Antiviral Agent Vidarabine

Shen, Wei, Kim, Jae-Seung, Mitchell, Stefanie, Kish, Phil, Kijek, Paul, Hilfinger, John

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2009

Language:

english

File:

PDF, 371 KB

english, 2009

50

Carrier-Mediated Prodrug Uptake to Improve the Oral Bioavailability of Polar Drugs: An Application to an Oseltamivir Analogue

Incecayir, Tuba, Sun, Jing, Tsume, Yasuhiro, Xu, Hao, Gose, Tomoka, Nakanishi, Takeo, Tamai, Ikumi, Hilfinger, John, Lipka, Elke, Amidon, Gordon L.

Journal:

Journal of Pharmaceutical Sciences

Year:

2016

Language:

english

File:

PDF, 910 KB

english, 2016